Current Issue : January-March Volume : 2014 Issue Number : 1 Articles : 9 Articles
Tablets and Capsules are the conventional dosage forms administered through the oral route of drug delivery which is the conventional and oldest route of drug delivery. This conventional route of delivery has always been troublesome to the patients especially geriatrics, pediatrics and patients with cardiac problems. Scientists have always searched for an alternative to this conventional route. Intraoral route of drug delivery has been proved to be non-invasive and most preferred alternative to the conventional route of drug delivery. United States prove to be the best market for such fast dissolve dosage forms. Sublingual route is the most preferred route as compared to other intraoral routes for drug delivery due to lesser thickness of the mucosal membrane. Mucosal membrane is divided into Epithelium, lamina propia and submucosa. The absorption of drug across mucosal membranes takes place via two routes: paracellular route and transcellular route. Drug should follow various criteria for being suitable for sublingual delivery. Sublingual route has more advantages than disadvantages and is developing rapidly as preferred route for drug delivery....
The objective of present work was to develop ocular inserts of levofloxacin and evaluate their potential for controlled ocular delivery. Conventional ophthalmic solution shows the poor bioavailability and therapeutic response due to many precorneal constraints. These constrains necessitates the controlled drug delivery to become a standard one in modern pharmaceutical era. Matrix type ocular inserts containing different combination of HPMC K 100 and Ethyl cellulose E7. The ocular insert were prepared by solvent casting technique and characterized thickness, hardness, weight variation, drug content, moisture loss, moisture absorbed, hydrolytic study, sterility study and In vitro drug release study. All the ocular inserts were found to be stable to all physiological studies. Among all batches F5 batch shows best result and optimized formula (HPMC K100 & EC N7 in 300 mg and 400 mg) sustained releases....
A novel wax matrix enteric coated tablet compare with polymer matrix enteric coated tablet of metoclopramide. The wax matrix tablet give more sustain effect as compare with polymer. The wax matrix tablet is prepared by melt granulation technique. Bioavailability is less and the half life is 2 hr. The dose of metoclopramide is 10 mg 4 times a day so due to this frequency of the drug taken is higher, through this approaches sustain delivery of the drug can be achieved. So, the patient compliance is increases by the reducing dose. A novel wax is use as matrixing agent like (Ozokerit and Candelilla wax) and compared with HPMC K 100 and EC and 8 batch formulated. Among them F2 and F4 batch containing Ozokerit and Candelilla wax shows maximum delay release....
Transdermal drug delivery system overcomes the problems associated with conventional oral dosage forms. It is painless delivery compare to intravenous delivery. MDTS (metered dose transdermal spray) is a monophasic solution containing drug with penetration enhancers. Combination of volatile-nonvolatile solvent system with penetration enhancers shows better penetration rate than the transdermal patch. On the application, MDTS forms thin non occlusive film of drug reservoir and release the drug in controlled manner for longer time. Steady state concentration is achieved from the stratum corneum reservoir. Dosing flexibility makes it more acceptable to the patient compared to transdermal patch....
Intranasal administration of therapeutic agents is practiced from ancient times, and the route gained more importance as the time passed by for category of drugs showing local action. Now days this route is gaining more importance due to its numerous advantages and has emerged as a Novel Drug Delivery System providing access to the therapeutic agents throughout the human body. Many different formulations for nasal delivery are available in market at present. Among all of these nasal gels are most appealing and promising formulations for systemic delivery of drugs due to the success achieved in overshadowing many different problems related to drug, formulation, or the physiological aspects of human body. Present review covers points related to intranasal delivery such as a brief look at anatomy physiology, factors affecting in detail, mechanism of absorption which have important effects on and contribute to the nasal formulation. Also some of the important aspects of gels such as the microstructure, and the polymers used which should be considered in the nasal gel formulation are included. Together these two aspects work as guideline for the successful formulation....
Nanoparticles are solid colloidal particles ranging in size from 1 to 1000nm that are utilized as drug delivery agents. Nanoparticle technology is expected to revolutionize the way in which drug delivery is conducted. Nanoparticle technologies have the capacity to improve drug efficacy, minimize side-effects, and provide targeted delivery. In this review an overview of various nanoparticles and Nanobased formulation were discussed....
Fast dissolving drug delivery system offer a solution for those patients having difficulty in swallowing tablet or capsule etc. Diclofenac Sodium, a non steroidal anti-inflammatory drug with analgesic and anti-inflammatory property was selected as the model drug. The present study investigated to development of novel fast dissolving oral films of Diclofenac Sodium which was by pass first pass metabolism, provide rapid onset of action and increasing the bioavailability of the drug. The fast dissolving films were prepared by solvent casting method by using HPMC K100M as film forming polymer, due to their hydrophilic nature and palatable taste. All the film formulations (F1-F3) were evaluated for their weight variations, thickness, surface pH, folding endurance, tensile strength, percentage elongation, in-vitro disintegration, drug content and in-vitro drug release studies....
The aim of present work was to formulate and evaluate Proniosomal gel formulation for treatment of psoriasis. Preformulation study like solubility, melting point was done. Drug and Excipient compatibility was determined by FT-IR spectroscopy and DSC study. Screening study was done for the selection of surfactant and lecithin as well as drug: lipid ratio by preparing Proniosomal gel formulation by co-acervation phase separation method. Span 60 and soya lecithin shows desirable result and it was selected for further optimization. Optimization was done by CCD with different concentration of span 60 and cholesterol. Particle size and entrapment efficiency was measure with other evaluating parameter. Drug diffusion from the proniosomal gel was study using Franz diffusion cell. The release kinetic data were subjected to different models in order to evaluate their release kinetics and mechanism and it follows Higuchi release kinetic model with diffusion base mechanism. Optimized batch F37 [Concentration of span 60(8.00) and concentration of cholesterol (2.00)] was prepared and optimized by center composite design and shows 85.55% drug diffusion in 24 hrs. The optimized batch no 3 was compared with marketed preparation and it shows better sustain release action than marketed preparation. The present study conclude that it is possible to prepare Proniosomal gel of Clobetsol propionate with desired criteria which enhance the permeability, gives the sustain release action and Hence improve the drug effect....
There are numerous approaches for delivering the drug at specific site, microspheres is one of the approach which produces sustained release action. Multiparticulate drug delivery system are suitable for achieving maximum bio availability and predetermined therapeutic effect, apart from this it also provide the advantage that it decreases the side effect and the chances of dose dumping so microspheres are proven to be one of the most effective approach to produce sustained release action. There are various types of microspheres like mucoadhesive, magnetic, floating microspheres which are responsible for targeted action of the drug. The purpose of the review is to assemble several types of microspheres, different manufacturing process, its applications and also various parameters to evaluate their productivity....
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